Injectable Vial Filling Machine

In-Line Vial Filling Machine: Precision Engineered for Sterile Injectable Packaging

Introducing our In-Line Vial Filling Machine, a state-of-the-art system designed as a critical injectable vial filling machine for the high-precision, aseptic pharmaceutical vial filling of parenteral drugs, vaccines, and biologics. Engineered with a clean, linear layout for optimal visibility and accessibility, this machine specializes in the accurate filling and sealing of vials within controlled environments. It provides a robust, scalable, and compliant solution for manufacturers requiring reliable performance in the demanding field of sterile injectable production.

capping part   The capping part of the linear vial filling machine is designed to provide secure and consistent sealing of pharmaceutical vials after the filling process. Vials are accurately guided into the capping station, where caps are automatically positioned and tightened with precise torque control. The system ensures proper alignment, minimizes vial movement, and prevents leakage or damage during high-speed operation. Compatible with various cap types and vial sizes, the capping module is constructed from GMP-compliant materials and delivers reliable, hygienic, and efficient performance for pharmaceutical small-vial production lines.

Purpose-Built for Aseptic Injectable Manufacturing

This machine is meticulously engineered to meet the stringent requirements of pharmaceutical vial filling for sterile injectables. The in-line (straight-line) conveyor design ensures gentle, singularized vial handling, minimizing turbulence and contamination risk during transport. It is equipped with precision peristaltic or piston pump filling technology, achieving volumetric accuracy within ±0.5% for critical doses ranging from 0.5mL to 100mL. Constructed with 316L stainless steel and designed for Clean-in-Place (CIP) and Steam-in-Place (SIP) protocols, this system serves as a dependable injectable vial filling machine capable of integrating into Grade A/B cleanroom suites or isolators.

Integrated Process for Complete Vial Integrity

Beyond mere filling, this system is designed as the core module for the complete filling and sealing of vials. It can be seamlessly coupled with automatic stoppering and crimping stations to create a unified, continuous operation. This integrated workflow ensures that after the precise liquid fill, vials are immediately transferred to a sterile stoppering unit and subsequently sealed with an aluminum overseal, all within a protected environment. This end-to-end approach is fundamental for maintaining sterility, achieving container-closure integrity (CCI), and streamlining the pharmaceutical vial filling process for lyophilized or liquid injectable products.

Core Features & Technical Advantages

• Linear, Visible Design: Straight-line configuration offers superior operator oversight, simplifies maintenance, and facilitates easier integration into isolator or RABS (Restricted Access Barrier System) lines.

• High-Precision Aseptic Filling: Advanced servo-driven pumps ensure exceptional accuracy and repeatability, essential for costly biologics and potent compounds in injectable vial filling machine applications.

• Closed System Technology: Utilizes peristaltic pumps with single-use tubing assemblies to create a closed fluid path, eliminating product exposure and cross-contamination.

• Seamless Sealing Integration: Engineered for direct connection to stoppering and crimping machines, enabling the complete filling and sealing of vials in a synchronized, automated sequence.

• Data Integrity & Compliance: 21 CFR Part 11-compliant control system with comprehensive electronic batch records, audit trails, and recipe management to support validated pharmaceutical vial filling operations.

Ideal Applications

• Sterile Injectables: Vaccines, antibiotics, monoclonal antibodies, chemotherapy drugs, and large-volume parenterals (LVPs).

• Lyophilized Products: Filling of solutions prior to freeze-drying, with integration capabilities for post-lyophilization stoppering.

• Ophthalmic/Otic Solutions: Sterile eye and ear drops requiring aseptic processing.

• Advanced Therapy Medicinal Products (ATMPs): Cell and gene therapy vectors.

Your Partner in Injectable Manufacturing

We provide end-to-end support for your critical pharmaceutical vial filling projects. From initial application analysis and machine configuration to factory acceptance testing (FAT), site validation (IQ/OQ/PQ), and operator training, we ensure this injectable vial filling machine is optimized for your product and fully compliant with global regulatory standards.