Vial Filling And Sealing Machine

Spray & Aerosol Filling Machine: Integrated Solution for Metered-Dose and Liquid Spray Packaging

Introducing our advanced Spray & Aerosol Filling Machine, a specialized vial filling equipment engineered to meet the unique demands of pharmaceutical, nasal, ophthalmic, and topical spray products. This precision system excels in accurately filling vials, bottles, and canisters with liquid formulations while seamlessly integrating the assembly and crimping of spray pumps, actuators, or aerosol valves. As a comprehensive vial filling and sealing machine for spray-based delivery systems, it ensures precise dosage, consistent performance, and secure closure integrity for metered-dose inhalers (MDIs), nasal sprays, and other pressurized or mechanical spray devices.

capping part   The capping part of the spray bottle filling machine is designed to securely apply spray pumps or caps with consistent and controlled torque. After filling, bottles are accurately guided into the capping station, where the system automatically positions and tightens each spray cap to ensure a leak-proof seal. The stable capping mechanism minimizes vibration and protects both the bottle and the spray pump from damage during operation. Compatible with various spray pump designs and bottle sizes, the capping module supports smooth, continuous production. Constructed from GMP-compliant materials, it delivers reliable sealing quality and hygienic performance for pharmaceutical spray bottle manufacturing.

lid pressing machine   The lid pressing machine of the spray bottle filling system is designed to accurately and securely press spray pumps or lids onto bottles after the filling process. Bottles are precisely positioned under the pressing heads, where controlled downward force ensures proper seating of each lid without damaging the pump mechanism or bottle neck. The system maintains stable, synchronized operation to achieve uniform pressing depth and consistent sealing quality. Suitable for various spray bottle and pump designs, the lid pressing machine is constructed from GMP-compliant materials and provides reliable, hygienic, and efficient performance for pharmaceutical spray bottle production lines.

Integrated Filling and Sealing for Complex Drug-Device Combinations

This machine is specifically designed to handle the complexities of spray product packaging, where the delivery device is integral to the drug's administration. It functions as a complete vial filling and sealing machine by performing two critical operations in one synchronized process: first, it accurately dispenses the liquid formulation (solution, suspension, or emulsion) into the container; second, it automatically places, secures, and crimps the spray pump or valve onto the container to create a hermetically sealed, ready-to-use unit. This integrated approach is essential for filling vials and bottles destined for respiratory, nasal, or ophthalmic use, where dosage accuracy and container closure integrity are paramount for patient safety and drug efficacy.

Precision Engineered for Pharmaceutical Spray Applications

As a specialized vial filling equipment for sprays, this system addresses key technical challenges such as maintaining formulation homogeneity, preventing clogging, and ensuring consistent shot weights. It utilizes high-precision piston or peristaltic filling technology capable of handling volumes from 5 µL to 50 mL with an accuracy of ±1% or better for metered doses. The machine is constructed with GMP-compliant materials (316L stainless steel, pharmaceutical-grade polymers) and supports cleanroom operation. Optional features include nitrogen purging to prevent oxidation, in-line pressure testing for aerosol cans, and 100% shot weight verification to guarantee each unit delivers the exact specified dose.

Core Features & Technical Advantages

• Dual-Function Automation: Combines precision liquid filling with automatic spray pump/valve insertion, crimping, and actuation testing in a single machine cycle.

• Metered-Dose Accuracy: Advanced filling and check-weighing systems ensure each spray delivers a consistent, pharmacopeia-compliant dose, critical for MDIs and nasal corticosteroids.

• Versatile Platform: Configurable for a wide range of containers (glass vials, PET bottles, aluminum cans) and spray components (nasal pumps, fine-mist actuators, aerosol valves).

• Aseptic & Containment Options: Designed for integration into Grade C cleanrooms with optional Grade A laminar flow or isolator interfaces for sterile spray products (e.g., nasal vaccines, preservative-free ophthalmics).

• Data Integrity & Traceability: 21 CFR Part 11-compliant PLC control with HMI provides full recipe management, electronic batch records, and traceability for every unit filled.

Ideal Applications

• Nasal Sprays: Steroid sprays, saline solutions, decongestants, and systemic drug delivery sprays.

• Metered-Dose Inhalers (MDIs): Albuterol, corticosteroids, and other respiratory therapeutics.

• Ophthalmic/Otic Sprays: Sterile eye washes and ear drop sprays.

• Topical & Dermatological Sprays: Antiseptics, local anesthetics, wound care, and foam-based products.

• Oral & Buccal Sprays: Pain management, nausea control, and fast-dissolving oral formulations.

Your Partner in Advanced Spray Drug Packaging

We offer end-to-end partnership for your spray packaging needs. Our support includes feasibility testing with your specific container-closure system, machine customization, factory acceptance testing (FAT), and comprehensive on-site qualification (IQ/OQ/PQ) support. We ensure this vial filling and sealing machine is fully validated to meet regulatory requirements for complex drug-device combination products.