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Vial Filling Machine Manufacturers

Vial liquid washing, drying, filling, and stoppering integrated line consists of the OCL series vertical ultrasonic bottle washer, ASMR tunnel hot air circulation oven, and the NLGF electronic vial liquid filling and stoppering machine. It can operate as an integrated line or be used as standalone equipment. It is designed for the production of 2–25 ml specification vials for aqueous solutions. The line can complete over 20 processes, including spray water injection, ultrasonic coarse bottle washing, outer wall water flushing, continuous secondary circulating water flushing of the bottle wall, primary air blowing, primary fresh water rinsing, two consecutive bottle air blowings, outer wall air blowing, preheating, drying and sterilization before depyrogenation, cooling, inflation, filling, post-filling, and stoppering.
  • INTRODUCTION
  • PARAMETER

Characteristic


Bottle washer adopts manipulator clamp bottle, is suitable for a varietyof specifications of schering bottles;

Reciprocating mixer washing bottle with water spray needle track insertway, cleaning effect is good, save energy. Prevent shaking from needleframe;

Mixer washing bottle the water pipe, injection needles completelyseparate,to avoid the cross contamination,in line with the gmprequirements;

Pieces out of the bottle inside the screw before adding buffer block,protect the screw, reduce broken bottle;

Pieces out of the bottle inside the whole import synchronous belt, theconnection piece of conveying ampoule bottle, operation is stable andreliable;

Oven adopts hot air circulation heating, temperature uniformity, energysaving;

Mixer oven has suddenlyloses power protection function, safeoperation;

Mixer oven can match circulating water cooling device, not loss roomair volume, reduce the risk of differential pressure imbalance in room,cooling effect is good.


Schering Bottles Liquid Filling, Washing, Drying & Stoppered Linkage Line: Precision for Demanding Formulations

 

Engineered for the high-value production of sensitive parenteral drugs, our Schering Bottles Linkage Line represents the pinnacle of integrated aseptic processing. This fully synchronized system is specifically designed to handle the stringent requirements of potent, lyophilized, or oxygen-sensitive products, ensuring absolute integrity from washing to stoppering.

As leading vial filling machine manufacturers, we have created a complete solution that eliminates manual intervention and contamination risk. The line integrates a high-velocity washing and drying system with a precision automatic vial filling machine and a gentle yet secure stoppering mechanism, all within a controlled, validated environment.


Key Features & Benefits:

 

  • Complete, Validated Aseptic Process: The linkage line provides a seamless, continuous workflow from initial bottle ingress to final stoppered vial egress. This integrated approach is designed to meet the most rigorous cGMP and FDA standards for sterile manufacturing.

  • Advanced Washing & Drying: The process begins with a high-pressure, multi-stage washing cycle using WFI and air knives, followed by a heated, laminar-flow drying tunnel to ensure bottles are impeccably clean, dry, and pyrogen-free before filling.

  • Precision Filling Under Inert Atmosphere: The heart of the line is our sophisticated automatic vial filling machine. It can be equipped with peristaltic or piston pumps for pinpoint volumetric accuracy and is often integrated with an inert gas purging system to protect oxygen-sensitive therapeutics.

  • Integrated Stoppering & Capping Readiness: Following filling, the system features a controlled stoppering station that partially seats the stopper (for lyophilization) or fully seats it. This is seamlessly coupled with an integrated vial capping machine that applies the overseal, ensuring a hermetic seal and preparing the product for its final crimping.

  • Robust Construction & Direct Expertise: Sourced directly from specialized vial filling machine manufacturers, this line is built with 316L stainless steel and features ultra-smooth, easy-to-clean surfaces. Our direct manufacturing ensures unparalleled technical support and process expertise.


Why Choose Our Linkage Line?

 

This is more than just an automatic vial filling machine; it is a complete production ecosystem. By integrating the washing, drying, filling, and stoppering processes, we provide a turnkey solution that maximizes yield, ensures product stability, and minimizes operational costs for critical injectables.


Ideal for Producing:

 

  • Potent Oncology and Hormone Therapies

  • Vaccines and Biologics

  • Other sensitive injectable formulations requiring stopper-sealed vials.

Secure Your Product's Integrity from Start to Finish.

Partner with expert vial filling machine manufacturers for a solution built for the most critical applications. Our linkage line, featuring a precision automatic vial filling machine and a reliable vial capping machine, guarantees the aseptic integrity your high-value products demand.

Contact us today to configure a line for your specific Schering bottle and formulation requirements.

Suitable Specification (ml) 2-25 2-25 2-25 2-25 2-25 2-25
Bottle Type Intl. Vial Intl. Vial Intl. Vial Intl. Vial Intl. Vial Intl. Vial
Number of Filling Heads 4 6 8 10 12 20
Production Capacity (bottles/min, 7ml) 120 180 200 300 400 500
Washing Pass Rate (%) ≥ 99 ≥ 99 ≥ 99 ≥ 99 ≥ 99 ≥ 99
Bottle Breakage Rate (%) ≤ 0.1 ≤ 0.1 ≤ 0.1 ≤ 0.1 ≤ 0.1 ≤ 0.1
Sterilization Temp. (°C) 300-350 300-350 300-350 300-350 300-350 300-350
Exhaust Air Volume (m³/h) 3000 3000 4100 4100 7500 8,000-10,000
Filling Accuracy (%) ≤ ±2.5 (Mech. Pump)
≤ ±0.5-1.0 (Servo Pump)
≤ ±2.5 (Mech. Pump)
≤ ±0.5-1.0 (Servo Pump)
≤ ±2.5 (Mech. Pump)
≤ ±0.5-1.0 (Servo Pump)
≤ ±2.5 (Mech. Pump)
≤ ±0.5-1.0 (Servo Pump)
≤ ±2.5 (Mech. Pump)
≤ ±0.5-1.0 (Servo Pump)
≤ ±2.5 (Mech. Pump)
≤ ±0.5-1.0 (Servo Pump)
Stoppering Pass Rate (%) ≥ 99 ≥ 99 ≥ 99 ≥ 99 ≥ 99 ≥ 99
Laminar Airflow Cleanliness Class 100 Class 100 Class 100 Class 100 Class 100 Class 100
Vacuum Purging Speed (L/S) 10 30 50 60 60 100
Power Capacity (kW) 66.6 75.6 75.6 106.6 106.6 212.6
Power Supply 380V 50Hz 380V 50Hz 380V 50Hz 380V 50Hz 380V 50Hz 380V 50Hz
Total Weight (kg) 6300 6300 7900 7900 9400 10900
Overall Dimensions (mm) 8,550×2,540×2,330 8,550×2,540×2,330 9,620×2,540×2,330 9,620×2,540×2,330 10,280×3,230×2,360 12,730×2,600×2,620
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