Vial Filling System

Ophthalmic Solution (Eye Drop) Filling Machine: Precision System for Sterile Single and Multi-Dose Packaging

Introducing our dedicated Ophthalmic Solution (Eye Drop) Filling Machine, a precision-engineered vial filling system designed to meet the stringent sterility, accuracy, and regulatory demands of ophthalmic and otic liquid manufacturing. This advanced technology ensures high-precision automatic vial filling for single-dose containers (e.g., blow-fill-seal ampoules) and multi-dose bottles with integrated dropper tips. Engineered for cleanroom and aseptic environments, this machine can also be configured as a fully integrated automatic vial filling and stoppering machine for multi-dose dropper bottle assembly, providing a complete, tamper-evident packaging solution for sensitive sterile solutions.

capping part   The capping part of the ophthalmic solution inner-stopper and outer-cap filling machine is designed to securely seal vials immediately after filling. The system accurately positions and inserts the inner stopper, followed by precise application of the outer cap, ensuring uniform torque and leak-proof closure. The mechanism maintains stable vial handling to prevent spillage or damage, while accommodating various vial sizes and cap types. Constructed from GMP-compliant materials, the capping module guarantees hygienic operation and reliable sealing, meeting the stringent quality and safety standards required for ophthalmic pharmaceutical production.

filling part   The filling part of the ophthalmic solution inner-stopper and outer-cap filling machine is engineered for precise and contamination-free dosing of eye drops and other sterile liquid formulations. Vials are accurately positioned under high-precision filling nozzles, which deliver consistent volumes with minimal splashing or foaming. The system’s servo-controlled metering ensures repeatable accuracy while maintaining gentle handling to protect sensitive ophthalmic products. Anti-drip nozzles and hygienic design minimize product loss and contamination. Manufactured with GMP-compliant materials, the filling module provides reliable, efficient, and sterile operation for modern ophthalmic pharmaceutical production lines.

Engineered for Aseptic Ophthalmic Manufacturing

This machine is purpose-built for sterile ocular and aural pharmaceuticals, where product integrity, precise dosage, and container closure integrity are paramount. The system incorporates ultra-clean design principles with laminar airflow integration to maintain ISO 5 (Grade A) conditions during the critical filling process. It utilizes advanced peristaltic or micro-piston pump technology to achieve unparalleled accuracy (±1% or better) for small fill volumes (0.2 mL to 15 mL), crucial for unit-dose efficacy and patient safety. As a comprehensive vial filling system, it handles the unique challenges of low-viscosity, often preservative-free formulations, preventing oxidation and microbial ingress.

Seamless Automation from Filling to Final Closure

Our system excels in providing complete automatic vial filling and closure integration. For multi-dose dropper bottles, the machine operates as an automatic vial filling and stoppering machine, performing a seamless sequence: precise liquid filling, automatic insertion of a sterile rubber bulb or dropper tip, and secure screw-capping or snap-capping to create a leak-proof, tamper-evident seal. This integrated process eliminates manual handling between stages, dramatically reducing contamination risk, particulate generation, and production errors—essential for compliance with stringent pharmacopeial standards (e.g., USP <797>, <800>, EU Annex 1).

Key Features & Technical Advantages

• Ultra-High Precision Filling: Micro-dosing technology ensures accuracy within ±1% for small volumes, critical for expensive ophthalmic drugs (e.g., biologics, anti-VEGF agents).

• Aseptic & Containment Design: Constructed with 316L stainless steel, featuring CIP/SIP capabilities, and designed for seamless integration into isolators or RABS for aseptic processing.

• Flexible Container Handling: Compatible with a wide range of ophthalmic containers: LDPE dropper bottles, glass vials with dropper assemblies, and unit-dose BFS (Blow-Fill-Seal) containers.

• Nitrogen Purging & Headspace Control: Integrated inert gas (N₂) purging option to displace oxygen in the headspace, extending the shelf-life of oxygen-sensitive formulations.

• Advanced Control & Data Integrity: 21 CFR Part 11-compliant PLC system with HMI provides full recipe management, electronic batch records, and comprehensive alarm logging for complete traceability.

• Gentle Product Handling: Low-shear filling pumps and smooth container transport protect sensitive proteins and viscosified solutions from degradation.

Ideal Applications

• Prescription Eye Drops: Antibiotics, steroids, glaucoma medications, dry eye treatments (cyclosporine, lifitegrast).

• Over-the-Counter (OTC) Ophthalmics: Lubricating eye drops, redness relievers, and allergy relief solutions.

• Otic (Ear) Solutions: Antibiotic and anti-inflammatory ear drops.

• Surgical & Diagnostic Irrigants: Sterile balanced salt solutions (BSS) and other ocular surgical fluids.

• Advanced Ophthalmic Therapies: Cell-based therapies and novel drug delivery systems in development.

Your Partner in Ophthalmic Packaging Excellence

We provide more than machinery; we offer a validated packaging solution. Our partnership includes application testing with your specific container-closure system, full factory acceptance testing (FAT), and comprehensive support for site installation, qualification (IQ/OQ/PQ), and operator training. We ensure this vial filling system is optimized for your product’s stability, sterility, and regulatory requirements.